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Every time a individual no more requires therapy with oxycodone, it could be a good idea to taper the dose gradually to stop indications of withdrawal. In absence of enough pain Manage, the possibility of hyperalgesia, tolerance and development of fundamental disorder should be considered (see section four.four).Breastfeeding Administration to nurs
ROXICODONE® should be used with Extraordinary caution in individuals with major Persistent obstructive pulmonary condition or cor pulmonale, and in people possessing considerably decreased respiratory reserve, hypoxia, hypercapnia, or pre-present respiratory melancholy.Oxycodone could enrich the neuromuscular blocking motion of skeletal muscle rel